This 3-day course will provide students with a broad training in the drug discovery process. Using a combination of lectures and group problem solving / tutorial sessions will learn about the various stages of involved in developing new drugs. The provisional list of topics covered will include:
Target Identification and Validation: Molecular Biology in Medicinal Chemistry; Target-Based and Phenotypic Screening, Assay development.
Drug design: Molecular Modeling, Structure-guided Drug Design, Fragment based drug discovery, biophysical methods, Chemoinformatics.
Lead Optimization: Hit-to-Lead Process in Drug Discovery, Improving
Drug Candidates by Design, Bioisosteres, Structure-Activity Relationships (SAR) and QSAR
Physical Properties: Drug-like Properties in Drug Discovery, Toxicology in Drug Discovery, Pharmacokinetics and Drug Metabolism, Methodologies for Optimizing Drug Clearance
Case Histories of Drug Discovery for NTDs
Target Identification and Validation: Molecular Biology in Medicinal Chemistry; Target-Based and Phenotypic Screening, Assay development.
Drug design: Molecular Modeling, Structure-guided Drug Design, Fragment based drug discovery, biophysical methods, Chemoinformatics.
Lead Optimization: Hit-to-Lead Process in Drug Discovery, Improving
Drug Candidates by Design, Bioisosteres, Structure-Activity Relationships (SAR) and QSAR
Physical Properties: Drug-like Properties in Drug Discovery, Toxicology in Drug Discovery, Pharmacokinetics and Drug Metabolism, Methodologies for Optimizing Drug Clearance
Case Histories of Drug Discovery for NTDs